Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → Methyl 2-(4,6-dimethoxypyrimidin-2-yl)oxybut-2-enoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Methyl 2-hydroxybut-3-enoate | HCID 545123 | — |
| 반응물 | 4,6-Dimethoxy-2-(methylsulfonyl)pyrimidine | HCID 838363 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 용매 | Methyl Ethyl Ketone | HCID 6569 | — |
| 생성물 | Methyl 2-(4,6-dimethoxypyrimidin-2-yl)oxybut-2-enoate | HCID 53952661 | 78.1% |
반응 단계
A mixture of methyl 2-hydroxybut-3-enoate (0.80g, 6.9mmol), 4,6-dimethoxy-2-methanesulphonylpyrimidine (1.50g, 6.9mmol) and potassium carbonate (1.04g, 7.6mmol) in methyl ethyl ketone (100ml) was refluxed for 12 hours. The reaction mixture was filtered and the filtrate evaporated in vacuo. Flash column chromatography (silica, 1.5% methanol in chloroform) of the residue gave the title compound (1.37g, 78% yield by weight).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05139563 |
| 출처 데이터셋 | uspto-grants-1992_08 |
| ORD ID | ord-926200faf6b44bfaa25326ff0c79f915 |
| 출처 메모 | uspto-grants-1992_08 |