Ammonia → 3-chloro-4-(trifluoromethoxy)benzamide

HRID 847541노트

반응식

HRID 847541 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][C:12]([F:15])([F:14])[F:13])[C:5](F)=[O:6].[NH3:16]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][C:12]([F:15])([F:14])[F:13])[C:5]([NH2:16])=[O:6]

참가 물질

3

반응물 2

HCID 222AmmoniaHCID 198817533-Chloro-4-(trifluoromethoxy)benzoyl fluoride

생성물 1

HCID 27738443-chloro-4-(trifluoromethoxy)benzamide

실험 절차

242.5 g (1 mole) of 3-chloro-4-trifluoromethoxybenzoyl fluoride were allowed to drip into 500 ml of 25% strength by weight aqueous ammonia solution with ice cooling, the mixture was then stirred for a further 30 minutes and the precipitate which deposited was filtered off with suction. 227 g of product having a melting point of 98° C. were obtained. This corresponds to a crude yield of 95% of theory.

후처리

  1. filtrationthe precipitate which deposited was filtered off with suction
  2. customwere obtained

출처 및 근거

ORD 기록
ord-97dadc69b0974f93b253618bda7394a5
출처 데이터셋
uspto-grants-1992_08
특허 번호
US05142092

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