Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → HCID 86686620, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | 1-(2-Pyrimidinyl)piperazine | HCID 88747 | — |
| 반응물 | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| 반응물 | (2,4,5-Tribromo-imidazol-1-yl)-acetic acid | HCID 86686618 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | HCID 86686620 | HCID 86686620 | — |
반응 단계
7.3 mL 2-piperazin-1-yl-pyrimidine was added to a mixture of 17 g (2,4,5-tribromo-imidazol-1-yl)-acetic acid, 16.6 g TBTU, 7.3 mL TEA and 100 mL DMF. The reaction mixture was stirred for 2 h at RT and subsequently added to water. The precipitate was filtered to give 23 g desired product. Rt: 0.93 (method B), ESI+: 507
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08846948B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-3c9d00cd6745421b9277a10b4b73c6d5 |
| 출처 메모 | uspto-grants-2014_09 |