Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(2-Pyrimidinyl)piperazine → 2-(2,4-Diphenyl-imidazol-1-yl)-1-(4-pyrimidin-2-yl-piperazin-1-yl)-ethanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(2-Pyrimidinyl)piperazine | HCID 88747 | — |
| 반응물 | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| 반응물 | (2,4-Diphenyl-imidazol-1-yl)-acetic acid | HCID 86686623 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-(2,4-Diphenyl-imidazol-1-yl)-1-(4-pyrimidin-2-yl-piperazin-1-yl)-ethanone | HCID 71586582 | 48.4% |
반응 단계
40 mg 2-piperazin-1-yl-pyrimidine was added to 70 mg (2,4-diphenyl-imidazol-1-yl)-acetic acid, 80 mg TBTU, 50 μL TEA in 1 mL DMF. The reaction was stirred overnight at RT. The mixture was purified by HPLC to give 50 mg desired product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08846948B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-000f2c008bf444348603f18d2754f9fe |
| 출처 메모 | uspto-grants-2014_09 |