Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → 4-Chloro-2-methoxybenzothiazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 2-Bromo-4-chlorobenzothiazole | HCID 77178 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4-Chloro-2-methoxybenzothiazole | HCID 4141969 | 93.8% |
반응 단계
2-Bromo-4-chlorobenzothiazole (6.21 g, 0.025 mole) and 94% sodium hydroxide (1.57 g, 0.037 mole) were added to methanol (100 c.c.), and the mixture was heated under reflux for 30 minutes. After cooling, water (100 c.c.) was added to the reaction solution, followed by ice-cooling. The deposited crystals were filtered and washed with water to obtain 4.68 g of 2-methoxy-4-chlorobenzothiazole. Yield 93.8%, purity 99.3%, m.p. 55°-57° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04293702 |
| 출처 데이터셋 | uspto-grants-1981_10 |
| ORD ID | ord-6e26b00862f84353ab12bbfba02506a2 |
| 출처 메모 | uspto-grants-1981_10 |