Methanol → 4-Chloro-2-methoxybenzothiazole

HRID 847795

반응식

HRID 847795 반응식
Br[C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[C:7]([Cl:11])[C:5]=2[N:6]=1.[OH-:12].[Na+].[CH3:14]O>O>[CH3:14][O:12][C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[C:7]([Cl:11])[C:5]=2[N:6]=1

참가 물질

5

반응물 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 771782-Bromo-4-chlorobenzothiazole

생성물 1

HCID 41419694-Chloro-2-methoxybenzothiazole수율 93.8%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

2-Bromo-4-chlorobenzothiazole (6.21 g, 0.025 mole) and 94% sodium hydroxide (1.57 g, 0.037 mole) were added to methanol (100 c.c.), and the mixture was heated under reflux for 30 minutes. After cooling, water (100 c.c.) was added to the reaction solution, followed by ice-cooling. The deposited crystals were filtered and washed with water to obtain 4.68 g of 2-methoxy-4-chlorobenzothiazole. Yield 93.8%, purity 99.3%, m.p. 55°-57° C.

후처리

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 30 minutes
  3. temperatureAfter cooling
  4. temperaturecooling
  5. filtrationThe deposited crystals were filtered
  6. washwashed with water

출처 및 근거

ORD 기록
ord-6e26b00862f84353ab12bbfba02506a2
출처 데이터셋
uspto-grants-1981_10
특허 번호
US04293702

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