Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 2-n-Propoxy-4-chlorobenzothiazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 2,4-Dichlorobenzothiazole | HCID 77177 | — |
| 반응물 | 2-Bromo-4-chlorobenzothiazole | HCID 77178 | — |
| 용매 | 1-Propanol | HCID 1031 | — |
| 생성물 | 2-n-Propoxy-4-chlorobenzothiazole | HCID 12766007 | 97.7% |
반응 단계
A mixture (11.30 g, 0.05 mole) of 2-bromo-4-chlorobenzothiazole and 2,4-dichlorobenzothiazole and 94% sodium hydroxide (2.34 g, 0.055 mole) in n-propanol (100 c.c.) was heated under reflux for 1 hour. Water was added and the alcohol was distilled azeotropically together with water. The resulting oily substance was extracted with chloroform, and the chloroform layer was washed with water. The solvent was removed under reduced pressure to obtain 11.12 g of 2-n-propoxy-4-chlorobenzothiazole as a yellow viscous liquid. Yield 97.7%, purity 98.9%, b.p. 106°-108° C./0.12 mmHg.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04293702 |
| 출처 데이터셋 | uspto-grants-1981_10 |
| ORD ID | ord-705986d35b744ee8a86accc645a337d5 |
| 출처 메모 | uspto-grants-1981_10 |