Water → 2-n-Propoxy-4-chlorobenzothiazole

HRID 847799

반응식

HRID 847799 반응식
Br[C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[C:7]([Cl:11])[C:5]=2[N:6]=1.ClC1S[C:15]2[CH:21]=CC=C(Cl)[C:16]=2N=1.[OH-:23].[Na+].O>C(O)CC>[CH2:21]([O:23][C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[C:7]([Cl:11])[C:5]=2[N:6]=1)[CH2:15][CH3:16]

참가 물질

6

반응물 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 771772,4-DichlorobenzothiazoleHCID 771782-Bromo-4-chlorobenzothiazole

생성물 1

HCID 127660072-n-Propoxy-4-chlorobenzothiazole수율 97.7%

시약·촉매·용매 1

HCID 10311-Propanol용매

실험 절차

A mixture (11.30 g, 0.05 mole) of 2-bromo-4-chlorobenzothiazole and 2,4-dichlorobenzothiazole and 94% sodium hydroxide (2.34 g, 0.055 mole) in n-propanol (100 c.c.) was heated under reflux for 1 hour. Water was added and the alcohol was distilled azeotropically together with water. The resulting oily substance was extracted with chloroform, and the chloroform layer was washed with water. The solvent was removed under reduced pressure to obtain 11.12 g of 2-n-propoxy-4-chlorobenzothiazole as a yellow viscous liquid. Yield 97.7%, purity 98.9%, b.p. 106°-108° C./0.12 mmHg.

후처리

  1. temperatureunder reflux for 1 hour
  2. distillationthe alcohol was distilled azeotropically together with water
  3. extractionThe resulting oily substance was extracted with chloroform
  4. washthe chloroform layer was washed with water
  5. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-705986d35b744ee8a86accc645a337d5
출처 데이터셋
uspto-grants-1981_10
특허 번호
US04293702

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