Benzoyl isothiocyanate → N-benzoyl-N'-[2-(2-pyrazinylmethylthio)ethyl]thiourea

반응식

[NH2:1][CH2:2][CH2:3][S:4][CH2:5][C:6]1[CH:11]=[N:10][CH:9]=[CH:8][N:7]=1.[C:12]([N:20]=[C:21]=[S:22])(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[C:12]([NH:20][C:21]([NH:1][CH2:2][CH2:3][S:4][CH2:5][C:6]1[CH:11]=[N:10][CH:9]=[CH:8][N:7]=1)=[S:22])(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

반응물 2

HCID 68284Benzoyl isothiocyanate

HCID 129234132-[(2-Aminoethyl)thiomethyl]pyrazine

생성물 1

HCID 20557817N-benzoyl-N'-[2-(2-pyrazinylmethylthio)ethyl]thiourea

실험 절차

By the procedure of Example 18, 2-[(2-aminoethyl)-thiomethyl]pyrazine is reacted with benzoyl isothiocyanate to give N-benzoyl-N'-[2-(2-pyrazinylmethylthio)ethyl]thiourea. Removing the benzoyl group by the procedure of Example 18 gives N-[2-(2-pyrazinylmethylthio)ethyl]thiourea.

출처 및 근거

ORD 기록: ord-aa0dd2614a0340fc851be6e7f5bab22d
출처 데이터셋: uspto-grants-1981_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04293697

반응 노트

불러오는 중…