Benzoyl isothiocyanate → N-benzoyl-N'-[2-(2-pyrimidylmethylamino)ethyl]thiourea

반응식

[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[CH2:7][NH:8][CH2:9][CH2:10][NH2:11].[C:12]([N:20]=[C:21]=[S:22])(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[C:12]([NH:20][C:21]([NH:11][CH2:10][CH2:9][NH:8][CH2:7][C:2]1[N:3]=[CH:4][CH:5]=[CH:6][N:1]=1)=[S:22])(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

반응물 2

HCID 68284Benzoyl isothiocyanate

HCID 20557649N-(2-pyrimidylmethyl)ethylenediamine

생성물 1

HCID 20557690N-benzoyl-N'-[2-(2-pyrimidylmethylamino)ethyl]thiourea

실험 절차

By the procedure of Example 46, N-(2-pyrimidylmethyl)ethylenediamine is reacted with benzoyl isothiocyanate to give N-benzoyl-N'-[2-(2-pyrimidylmethylamino)-ethyl]thiourea.

출처 및 근거

ORD 기록: ord-6d4def892b704a3c8a0e83a3ee9cc6b6
출처 데이터셋: uspto-grants-1981_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04293697

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