Hydrazine → 2-Hydrazino-9-(2-hydroxyethoxymethyl)adenine

HRID 848078노트

반응식

HRID 848078 반응식
Cl[C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH2:11][O:12][CH2:13][CH2:14][OH:15])=[C:4]([NH2:16])[N:3]=1.[NH2:17][NH2:18]>>[NH:17]([C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH2:11][O:12][CH2:13][CH2:14][OH:15])=[C:4]([NH2:16])[N:3]=1)[NH2:18]

참가 물질

3

반응물 2

HCID 9321HydrazineHCID 128995862-Chloro-9-(2-hydroxyethoxymethyl)adenine

생성물 1

HCID 867364332-Hydrazino-9-(2-hydroxyethoxymethyl)adenine

실험 절차

2-Chloro-9-(2-hydroxyethoxymethyl)adenine (0.83 g) was added with stirring to 95% hydrazine (11 ml) and the resulting solution stirred 1 hour under nitrogen. Excess hydrazine was removed by distillation in a rotary evaporator at a bath temperature of 30° C. followed by co-evaporation twice with ethyl acetate. The residue was thoroughly triturated with methanol to give a quantitative yield (0.8 g) of white to cream colored-2-hydrazino-9-(2-hydroxyethoxymethyl) adenine, m.p. 220°-222° C.

후처리

  1. customExcess hydrazine was removed by distillation in a rotary evaporator at a bath temperature of 30° C.
  2. customThe residue was thoroughly triturated with methanol

출처 및 근거

ORD 기록
ord-4c7de4d0072e41c9b73fedd8fd7d0e03
출처 데이터셋
uspto-grants-1981_10
특허 번호
US04294831

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