(R)-Benzyl (1-amino-1-oxo-3-phenylpropan-2-yl)carbamate → (2R)-2-amino-3-phenylpropanamide

HRID 84815

반응식

HRID 84815 반응식
[NH2:1][C:2](=[O:22])[C@H:3]([NH:11]C(=O)OCC1C=CC=CC=1)[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>CO.[Pd]>[NH2:11][C@@H:3]([C:2]([NH2:1])=[O:22])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

참가 물질

4

반응물 1

HCID 68077307(R)-Benzyl (1-amino-1-oxo-3-phenylpropan-2-yl)carbamate

생성물 1

HCID 7000171(2R)-2-amino-3-phenylpropanamide수율 98.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of (R)-benzyl 1-amino-1-oxo-3-phenylpropan-2-ylcarbamate (910 mg, 3.05 mmol) and Pd—C (10%, 200 mg) in MeOH (20 mL) was hydrogenated under balloon H2 for 16 h. It was filtered through celite. The filtrate was concentrated in vacuo to give D-phenylalanine amide as a white solid (493 mg).

후처리

  1. filtrationIt was filtered through celite
  2. concentrationThe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-3a46015da6164ff6a39edee6f71e7158
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846928B2

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