Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylethylamine → (R)-2-(3-bromo-4-cyanophenylamino)-3-phenylpropanamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 2-Bromo-4-fluorobenzonitrile | HCID 118939 | — |
| 반응물 | (2R)-2-amino-3-phenylpropanamide | HCID 7000171 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | (R)-2-(3-bromo-4-cyanophenylamino)-3-phenylpropanamide | HCID 67509091 | 23.3% |
반응 단계
A solution of 2-bromo-4-fluorobenzonitrile (255 mg, 1.27 mmol), D-phenylalanine amide (220 mg, 1.34 mmol) and DIEA (0.466 mL, 2.68 mmol) in DMSO (3 mL) was stirred at 100 C for 18 h. The mixture was then purified by HPLC to give (R)-2-(3-bromo-4-cyanophenylamino)-3-phenylpropanamide (102 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08846928B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-e9254a9343a04fa4b0ed05ac1403204f |
| 출처 메모 | uspto-grants-2014_09 |