1,2-Dichloroethane → (R)-2-(3-bromo-4-cyanophenylamino)-2-phenylacetamide

참여 물질

역할	이름	HCID	투입량
반응물	1,2-Dichloroethane	HCID 11	—
반응물	Ammonium Hydroxide	HCID 14923	—
반응물	1-Hydroxybenzotriazole hydrate	HCID 2796029	—
반응물	(R)-2-(3-bromo-4-cyanophenylamino)-2-phenylacetic acid	HCID 67509737	—
용매	Water	HCID 962	—
용매	Dimethylformamide	HCID 6228	—
용매	Ethyl Acetate	HCID 8857	—
생성물	(R)-2-(3-bromo-4-cyanophenylamino)-2-phenylacetamide	HCID 67508351	87.5%

반응 단계

To a solution of (R)-2-(3-bromo-4-cyanophenylamino)-2-phenylacetic acid (90 mg, 0.27 mmol) and HOBt hydrate (62 mg, 0.40 mmol) in DMF (2 mL), EDC (74 mg, 0.38 mmol) was added. The mixture was stirred for 60 min. Then conc. NH4OH (0.100 mL, ˜1.40 mmol) was added. It was stirred for 18 h. Water and EtOAc were added. The organic phase was separated, washed with 5% NaHCO3, dried over Na2SO4, concentrated in vacuo to give (R)-2-(3-bromo-4-cyanophenylamino)-2-phenylacetamide (78 mg).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08846928B2
출처 데이터셋	uspto-grants-2014_09
ORD ID	ord-c6573f14154f44da8daace8aedf63950
출처 메모	uspto-grants-2014_09