[CH:1]([C:4]1([C:10]([OH:12])=[O:11])[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1)([CH3:3])[CH3:2].S(Cl)([Cl:15])=O.[CH2:17]([NH2:19])[CH3:18]>CCOCC.O>[CH:1]([C:4]1([C:10]([Cl:15])=[O:12])[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1)([CH3:3])[CH3:2].[CH2:17]([NH:19][C:10]([C:4]1([CH:1]([CH3:3])[CH3:2])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9]1)=[O:11])[CH3:18]1-isopropylcyclohexanoyl chloride was prepared from 1-isopropylcyclohexanoic acid and thionyl chloride. A solution of this acid chloride (2.6 g) in ether (25 ml) was added dropwise to a stirred solution of ethylamine (5 ml of a 70% solution in water) in ether (100 ml). After 2 hours the ethereal solution was washed with dilute hydrochloric acid and water, dried (MgSO4) and concentrated to give a white solid. This was recrystallised from petroleum ether (bp. 40°-60°) to give N-ethyl-1-isopropylcyclohexanamide, mp. 101°-2°.
불러오는 중…
