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Water → 1-(4-Chlorophenyl)-3-cyano-1,2-dihydroquinoxalin-2-one

HRID 848477
노트
인쇄 미리보기

반응식

HRID 848477 반응식
Cl[C:2]1[C:3](=[O:19])[N:4]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)[C:5]2[C:10]([N:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.[C-:20]#[N:21].[K+].O>CN(C)C=O>[Cl:18][C:15]1[CH:16]=[CH:17][C:12]([N:4]2[C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[N:11]=[C:2]([C:20]#[N:21])[C:3]2=[O:19])=[CH:13][CH:14]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 962WaterHCID 9032Potassium CyanideHCID 205654663-Chloro-1-(4-chlorophenyl)-1,2-dihydroquinoxalin-2-one

생성물 1

HCID 205654901-(4-Chlorophenyl)-3-cyano-1,2-dihydroquinoxalin-2-one수율 65.1%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
140 °C
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실험 절차

A mixture of 3-chloro-1-(4-chlorophenyl)-1,2-dihydroquinoxalin-2-one (10.0 g) and potassium cyanide (2.5 g) in dry dimethylformamide (100 ml) was heated at 140° C. for 24 hours. The mixture was added to water and the product was extracted into chloroform. Evaporation of the solvent and crystallisation of the residue from ethanol gave the title compound (6.3 g) mp 232°-235° C.

후처리

  1. extractionthe product was extracted into chloroform
  2. customEvaporation of the solvent and crystallisation of the residue from ethanol

출처 및 근거

ORD 기록
ord-943ac14bea574d5d86eabdb074bc7e10
출처 데이터셋
uspto-grants-1981_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04296114

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