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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 84860생성일: 2026년 10월 25일

tert-butyl (1S,2R)-2-(4-cyano-2-fluoro-5-(3-phenylisoxazol-5-ylamino)phenylamino)cyclohexylcarbamate → 4-((1R,2S)-2-aminocyclohexylamino)-5-fluoro-2-(3-phenylisoxazol-5-ylamino)benzonitrile

https://huagongshe.com/reaction/84860

반응식

참여 물질

역할이름HCID투입량
반응물tert-butyl (1S,2R)-2-(4-cyano-2-fluoro-5-(3-phenylisoxazol-5-ylamino)phenylamino)cyclohexylcarbamateHCID 86666162—
용매Trifluoroacetic acidHCID 6422—
생성물4-((1R,2S)-2-aminocyclohexylamino)-5-fluoro-2-(3-phenylisoxazol-5-ylamino)benzonitrileHCID 67776400160.8%

반응 단계

The compound tert-butyl (1S,2R)-2-(4-cyano-2-fluoro-5-(3-phenylisoxazol-5-ylamino)phenylamino)cyclohexylcarbamate (40 mg, 0.081 mmol) was dissolved in TFA (1.0 mL). After 20 min, TFA was removed in vacuo to give 4-((1R,2S)-2-aminocyclohexylamino)-5-fluoro-2-(3-phenylisoxazol-5-ylamino)benzonitrile (51 mg).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08846928B2
출처 데이터셋uspto-grants-2014_09
ORD IDord-0620ba259f8c4a54b9d8fe226dc1559c
출처 메모uspto-grants-2014_09