참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-(Tributylstannyl)-1,3-thiazole | HCID 2763259 | — |
| 반응물 | 5-Iodo-pyridin-3-ylamine | HCID 24229188 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 5-(1,3-Thiazol-2-yl)pyridin-3-amine | HCID 67509708 | 84% |
반응 단계
The mixture of 2-tributylstannylthiazole (2.24 g, 6.00 mmol), 5-iodopyridin-3-ylamine (1.10 g, 5.00 mmol) and Pd(Ph3P)4 (580 mg, 0.5 mmol) in 50 mL toluene was degassed using Ar. The mixture was then stirred under Ar at 115° C. for 3 h. The mixture was concentrated and subjected to flash column (0 to 7% MeOH in DCM) to isolate 5-(thiazol-2-yl)pyridin-3-amine (740 mg, 84% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08846928B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_09 |
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| ORD ID | ord-565119b159954842a42e59d381fb848a |
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| 출처 메모 | uspto-grants-2014_09 |
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