3-[[2-[2-(3,4-Dimethoxyphenyl)ethylamino]-2-oxoethyl]amino]benzamide → 2-(3-carbamoylphenylamino)-N-(3,4-dimethoxyphenethyl)acetamide trihydrate

HRID 848735노트

반응식

HRID 848735 반응식
[C:1]([C:4]1[CH:5]=[C:6]([NH:10][CH2:11][C:12]([NH:14][CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[C:19]([O:25][CH3:26])[CH:18]=2)=[O:13])[CH:7]=[CH:8][CH:9]=1)(=[O:3])[NH2:2]>O>[OH2:3].[OH2:3].[OH2:3].[C:1]([C:4]1[CH:5]=[C:6]([NH:10][CH2:11][C:12]([NH:14][CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[C:19]([O:25][CH3:26])[CH:18]=2)=[O:13])[CH:7]=[CH:8][CH:9]=1)(=[O:3])[NH2:2]

참가 물질

3

반응물 1

HCID 1566513-[[2-[2-(3,4-Dimethoxyphenyl)ethylamino]-2-oxoethyl]amino]benzamide

생성물 1

HCID 221497912-(3-carbamoylphenylamino)-N-(3,4-dimethoxyphenethyl)acetamide trihydrate수율 225.8%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To 0.2 g of pulverized 2-(3-carbamoylphenylamino)-N-(3,4-dimethoxyphenethyl)acetamide was added 100 ml of water and the mixture was stirred at 60° to 65° C. for 30 minutes to dissolve the powder completely. The solution was then concentrated under reduced pressure at 60° C. until about 40 ml of residual liquid was left, and allowed to stand at room temperature overnight. The colorless needles precipitated were collected by filtration, washed with water and then air-dried by allowing to stand at room temperature to obtain 0.13 g of 2-(3-carbamoylphenylamino)-N-(3,4-dimethoxyphenethyl)acetamide trihydrate having a melting point of 54°-57° C.

후처리

  1. dissolutionto dissolve the powder completely
  2. concentrationThe solution was then concentrated under reduced pressure at 60° C. until about 40 ml of residual liquid
  3. waitwas left
  4. waitto stand at room temperature overnight
  5. customThe colorless needles precipitated
  6. filtrationwere collected by filtration
  7. washwashed with water
  8. customair-dried
  9. customto stand at room temperature

출처 및 근거

ORD 기록
ord-f584edcc0fe4495a936c2f46d3771082
출처 데이터셋
uspto-grants-1981_10
특허 번호
US04297357

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