Heptadecanoic Acid → Heptadecanoyl Chloride

HRID 848937

반응식

HRID 848937 반응식
[C:1]([OH:19])(=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17].S(Cl)([Cl:22])=O>C1CCCCC1>[C:1]([Cl:22])(=[O:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17]

참가 물질

4

반응물 2

HCID 10465Heptadecanoic Acid2회HCID 24386Thionyl Chloride2회

생성물 1

HCID 3516438Heptadecanoyl Chloride수율 81.6%

시약·촉매·용매 1

HCID 8078Cyclohexane용매

반응 조건

온도
80 °C

실험 절차

In a one L (liter) two-necked flask were placed 102.1 g (0.38 mol) of heptadecanoic acid and 200 milliliter (mL) of cyclohexane, and the flask was equipped with a 100 mL dropping funnel containing 67.3 g (0.57 mol) of thionyl chloride and a reflux tube. Then, the heptadecanoic acid was completely dissolved under heating and stirring of the flask in an oil bath at 80° C. Thereafter the thionyl chloride was added dropwise over a period of 2 hours, and further the oil bath was maintained at 80° C. for one hour. From the resultant reaction mixture were removed the cyclohexane and the thionyl chloride under reduced pressure by means of an aspirator. The resultant reaction mixture was subjected to vacuum distillation. Thus 88.5 g (0.31 mol) of heptadecanoyl chloride was obtained in a yield of 81.2% based on the fed heptadecanoic acid.

후처리

  1. customthe flask was equipped with a 100 mL
  2. temperatureunder heating
  3. temperaturefurther the oil bath was maintained at 80° C. for one hour
  4. customFrom the resultant reaction mixture
  5. customwere removed the cyclohexane
  6. customThe resultant reaction mixture
  7. distillationwas subjected to vacuum distillation

출처 및 근거

ORD 기록
ord-dc386b59b929450298c6b7b545141946
출처 데이터셋
uspto-grants-2000_01
특허 번호
US06010708

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