HCID 18403163, 화합물 → HCID 9949326, 화합물

HRID 849026노트

반응식

HRID 849026 반응식
C([O:8][C:9]([CH:11]([CH2:25][CH2:26][C:27]([O:29]CC1C=CC=CC=1)=[O:28])[CH2:12][P:13]([CH2:16][CH2:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)(=[O:15])[OH:14])=[O:10])C1C=CC=CC=1>O.[Pd]>[C:19]1([CH2:18][CH2:17][CH2:16][P:13]([CH2:12][CH:11]([CH2:25][CH2:26][C:27]([OH:29])=[O:28])[C:9]([OH:10])=[O:8])([OH:15])=[O:14])[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

참가 물질

4

반응물 1

HCID 18403163HCID 18403163, 화합물

생성물 1

HCID 9949326HCID 9949326, 화합물수율 89%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 962Water용매

실험 절차

2,4-Di(benzyloxycarbonyl)butyl(3-phenylpropyl)phosphinic acid (15) (1.4 g, 2.8 mmol) in 20 mL of water containing 150 mg of 10% Pd/C was hydrogenated on a Parr hydrogenator at 40 psi overnight. Filtration through a Celite pad followed by evaporation on high vacuum gave 0.8 g (89%) of 2-[(3-phenylpropylhydroxyphosphinyl)methyl]pentanedioic acid (4, R=CH2CH2CH2Ph)as a light yellow viscous oil).

후처리

  1. customwas hydrogenated on a Parr hydrogenator at 40 psi overnight
  2. filtrationFiltration through a Celite pad
  3. customfollowed by evaporation on high vacuum

출처 및 근거

ORD 기록
ord-b4447eb2dbcf462cac2b908d9cff2401
출처 데이터셋
uspto-grants-2000_01
특허 번호
US06011021

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