6-Benzylpyridin-2-amine → HCID 178507544, 화합물

HRID 849158

반응식

HRID 849158 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:3]=1>C(O)(=O)C.[Rh]>[NH:1]=[C:2]1[CH2:7][CH2:6][CH2:5][CH:4]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[NH:3]1

참가 물질

4

반응물 1

HCID 939026-Benzylpyridin-2-amine

생성물 1

HCID 178507544HCID 178507544, 화합물

시약·촉매·용매 2

HCID 23948Rhodium촉매HCID 176Acetic Acid용매

실험 절차

Example 298) A sample of the 2-amino-6-benzylpyridine product of Example 298 A was reduced in acetic acid under hydrogen atmosphere utilizing 5% Rh/C catalyst to afford 2-imino-6-benzylpiperidine as an oil. The oil was purified by C-18 reverse phase chromatography to give a white solid. The solid was dissolved in 1N HCl, lyophilized, and recrystallized from EtOH/EtOAc to give the title product as a white solid.

출처 및 근거

ORD 기록
ord-f969f49f24934845b7a38b501b51d7de
출처 데이터셋
uspto-grants-2000_01
특허 번호
US06011028

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