3-Amino-1-propanol → 220831-12-9

HRID 849170노트

반응식

HRID 849170 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:20]2[C:19]3[CH:18]=[CH:17][CH:16]=[C:15]([O:21][C:22]([F:25])([F:24])[F:23])[C:14]=3[N:13]=[C:12](Cl)[C:11]=2[CH2:10][CH2:9]1.[NH2:27][CH2:28][CH2:29][CH2:30][OH:31]>>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:20]2[C:19]3[CH:18]=[CH:17][CH:16]=[C:15]([O:21][C:22]([F:25])([F:24])[F:23])[C:14]=3[N:13]=[C:12]([NH:27][CH2:28][CH2:29][CH2:30][OH:31])[C:11]=2[CH2:10][CH2:9]1

참가 물질

3

반응물 2

HCID 90863-Amino-1-propanolHCID 11728593HCID 11728593, 화합물

생성물 1

HCID 9823252220831-12-9

실험 절차

1-(2-Methylphenyl)-4-chloro-6-trifluoromethoxy-2,3-dihydropyrrolo[3,2-c]quinoline(380 mg, 1.0 mmol) was dissolved in 3-amino-1-propanol(5 ml), then reacted at the same condition of Step 5 in the Example 1 to obtain 313 mg of desired compound as solid in 75% of yield.

후처리

  1. customreacted at the same condition of Step 5 in the Example 1

출처 및 근거

ORD 기록
ord-11d2aa36ee0e4b80bf045bd07a9b1f9e
출처 데이터셋
uspto-grants-2000_01
특허 번호
US06011044

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