Ammonia → HCID 19369817, 화합물

HRID 849174노트

반응식

HRID 849174 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:20]2[C:19]3[CH:18]=[CH:17][CH:16]=[C:15]([O:21][C:22]([F:25])([F:24])[F:23])[C:14]=3[N:13]=[C:12](Cl)[C:11]=2[CH:10]=[CH:9]1.[NH3:27]>>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:20]2[C:19]3[CH:18]=[CH:17][CH:16]=[C:15]([O:21][C:22]([F:25])([F:24])[F:23])[C:14]=3[N:13]=[C:12]([NH2:27])[C:11]=2[CH:10]=[CH:9]1

참가 물질

3

반응물 2

HCID 222AmmoniaHCID 17872147HCID 17872147, 화합물

생성물 1

HCID 19369817HCID 19369817, 화합물

실험 절차

1-(2-methylphenyl)-4-chloro-6-trifluoromethoxypyrrolo[3,2-c]quinoline(377 mg, 1.0 mmol) was dissolved in aqueous ammonia(10 ml), then reacted at the same condition of Step 3 in the Example 6 to obtain 29 mg of desired compound as solid in 8% of yield.

후처리

  1. customreacted at the same condition of Step 3 in the Example 6

출처 및 근거

ORD 기록
ord-aaf5d0ee37004382a547e3de80fe695a
출처 데이터셋
uspto-grants-2000_01
특허 번호
US06011044

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