Diethyl Ether → 4-(2-Bromoacetyl)-4-phenylpiperidine hydrobromide

HRID 849328노트

반응식

HRID 849328 반응식
[Br:1]Br.[BrH:3].[C:4]([C:7]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1)(=[O:6])[CH3:5].CCOCC>C(Cl)Cl>[BrH:1].[Br:3][CH2:5][C:4]([C:7]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]1)=[O:6]

참가 물질

5

반응물 3

HCID 3283Diethyl EtherHCID 24408BromineHCID 212004624-Acetyl-4-phenylpiperidine hydrobromide

생성물 1

HCID 227417564-(2-Bromoacetyl)-4-phenylpiperidine hydrobromide수율 93.4%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

7.9 g of bromine are added rapidly at RT to a suspension of 14 g of 4-acetyl-4-phenylpiperidine hydrobromide in 200 ml of DCM and the reaction mixture is stirred overnight at RT. It is diluted by the addition of 200 ml of ether and the precipitate formed is wrung and washed with ether to give 16.7 g of the expected product after drying under vacuum.

후처리

  1. customthe precipitate formed
  2. washwashed with ether

출처 및 근거

ORD 기록
ord-da05b1f1be2b4cde97eb3f95fed7f945
출처 데이터셋
uspto-grants-2000_01
특허 번호
US06011154

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