t-Butyl bromide → Ethyl 1-(4-tert-butoxy-3-cyanophenyl)pyrazole-4-carboxylate

반응식

[C:1]([C:3]1[CH:4]=[C:5]([N:10]2[CH:14]=[C:13]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH:12]=[N:11]2)[CH:6]=[CH:7][C:8]=1[OH:9])#[N:2].Br[C:21]([CH3:24])([CH3:23])[CH3:22]>>[C:21]([O:9][C:8]1[CH:7]=[CH:6][C:5]([N:10]2[CH:14]=[C:13]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH:12]=[N:11]2)=[CH:4][C:3]=1[C:1]#[N:2])([CH3:24])([CH3:23])[CH3:22]

참가 물질

반응물 2

HCID 10485t-Butyl bromide

HCID 15407383Ethyl 1-(3-cyano-4-hydroxyphenyl)pyrazole-4-carboxylate

생성물 1

HCID 19366018Ethyl 1-(4-tert-butoxy-3-cyanophenyl)pyrazole-4-carboxylate

실험 절차

The same reaction and treatment as in Example 5 using ethyl 1-(3cyano-4-hydroxyphenyl)pyrazole-4-carboxylate and 1-bromo-1,1-dimethylethane gives ethyl 1-(4-tert-butoxy-3-cyanophenyl)pyrazole-4-carboxylate.

출처 및 근거

ORD 기록: ord-3c4054984a5346f1a01ec90694c2ce79
출처 데이터셋: uspto-grants-2000_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06015829

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