2-Aminooctadecane-1,3-diol → 2-Hydroxyhexadecanoyl-D-erythro-dihydrosphingosine

HRID 850229

반응식

HRID 850229 반응식
[OH:1][CH:2]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])[C:3]([OH:5])=O.[NH2:20][CH:21]([CH:24]([OH:40])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH3:39])[CH2:22][OH:23]>C(OCC)(=O)C.CCCCCCC>[OH:1][CH:2]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])[C:3]([NH:20][CH:21]([CH:24]([OH:40])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH3:39])[CH2:22][OH:23])=[O:5]

참가 물질

5

반응물 2

HCID 31262-Aminooctadecane-1,3-diolHCID 928362-Hydroxyhexadecanoic acid

생성물 1

HCID 110280852-Hydroxyhexadecanoyl-D-erythro-dihydrosphingosine수율 70%

시약·촉매·용매 2

HCID 8857Ethyl Acetate용매HCID 8900Heptane용매

실험 절차

4.9 g (0.018 mol) of 2-hydroxyhexadecanoic acid and 5.4 g (0.018 mol) of 2-aminooctadecane-1,3-diol were mixed in a glass tube; the mixture was irradiated with microwaves with the aid of a Synthewave 402™ apparatus from Prolabo--frequency 2450±50 MHz--modulable power rating 300 W. After an irradiation of 15 minutes at 155° C.±5° C., the reaction mixture was solubilized at high temperature in a mixture of 80 ml of ethyl acetate and 20 ml of heptane. The precipitate obtained was recrystallized from ethanol and 7 g of expected pure product were obtained with a yield of 70%.

후처리

  1. customthe mixture was irradiated with microwaves with the aid of a Synthewave 402™ apparatus from Prolabo
  2. customAfter an irradiation of 15 minutes at 155° C.±5° C.
  3. customThe precipitate obtained
  4. customwas recrystallized from ethanol and 7 g of expected pure product
  5. customwere obtained with a yield of 70%

출처 및 근거

ORD 기록
ord-9977ff55ea654acc950804e583e4ba81
출처 데이터셋
uspto-grants-2000_01
특허 번호
US06017426

연결된 노트

불러오는 중…