Dichloromethane → Ethyl 1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate

HRID 850360

반응식

HRID 850360 반응식
ClCCl.[C:4]1([CH:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH2:13][CH2:12][NH:11]2)[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.Cl[C:21]([O:23][CH2:24][CH3:25])=[O:22]>C(N(CC)CC)C>[C:4]1([CH:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH2:13][CH2:12][N:11]2[C:21]([O:23][CH2:24][CH3:25])=[O:22])[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

참가 물질

5

반응물 3

HCID 6344DichloromethaneHCID 10928Ethyl chloroformateHCID 1001371,2,3,4-Tetrahydro-1-phenylisoquinoline

생성물 1

HCID 10423841Ethyl 1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

To a 130 ml dichloromethane solution containing 6.28 g of 1-phenyl-1,2,3,4-tetrahydroisoquinoline and 3.34 g of triethylamine, 3.1 ml of ethyl chloroformate was added dropwise under ice-cooling, followed by stirring at room temperature overnight. The reaction solution was washed successively with water, 1N hydrochloric acid, water and brine and then dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure, thereby 10.58 g of ethyl 1-phenyl-1,2,3,4-tetrahydro-2-isoquinolinecarboxylate was obtained as pale yellow oil.

후처리

  1. additionwas added dropwise under ice-
  2. temperaturecooling
  3. washThe reaction solution was washed successively with water, 1N hydrochloric acid, water and brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-d34a8cf1bdd142488f513847084b3196
출처 데이터셋
uspto-grants-2000_01
특허 번호
US06017927

연결된 노트

불러오는 중…