Water → 2-Benzyloxyphenylacetonitrile

(2-Hydro xyphenyl)acetonitrile (1.01 g, 0.0076 mol) was dissolved in DMF (10 ml), and to this solution were successively added benzyl bromide (0.90 ml, 0.0076 mol, 1.0 eq) and anhydrous potassium carbonate (2.1 g, 0.015 mol, 3.0 eq). The mixture was stirred with heating at 90° C. for 1.5 hours. The reaction mixture was cooled to room temperature, and water (10 ml) was added. The mixture was extracted twice with ethyl acetate (30 ml). The organic layers were combined, washed with saturated brine (60 ml) and dried over anhydrous sodium sulfate. The drying agent was filtered off, and the filtrate was concentrated under reduced pressure to give (2-benzyloxyphenyl)acetonitrile (2.04 g, 100%) as a colorless solid.

1. temperatureThe reaction mixture was cooled to room temperature
2. extractionThe mixture was extracted twice with ethyl acetate (30 ml)
3. washwashed with saturated brine (60 ml)
4. dry with materialdried over anhydrous sodium sulfate
5. filtrationThe drying agent was filtered off
6. concentrationthe filtrate was concentrated under reduced pressure

ORD 기록

ord-65b7b6d8a6394ec7a3867682c8823ee2

출처 데이터셋

uspto-grants-2000_01

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US06017919