Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Benzyloxybenzylamine → 4-Hydroxybenzylamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Benzyloxybenzylamine | HCID 4292845 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | HCID 178418390 | HCID 178418390 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-Hydroxybenzylamine | HCID 97472 | 85% |
반응 단계
10% Palladium-carbon catalyst (water content 50%, 50 mg) was added to a solution of 4-benzyloxybenzylamine (530 mg, 2.485 mmol, 1.0 eq) in THF (10 ml), and the mixture was stirred for 3 hours at room temperature in a stream of hydrogen. The reaction mixture was filtered through Celite, and the filtrate was concentrated under reduced pressure. The obtained residue was purified by column chromatography (n-hexane/ethyl acetate=1/1) to give 4-hydroxybenzylamine (260 mg, 85.0%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06017919 |
| 출처 데이터셋 | uspto-grants-2000_01 |
| ORD ID | ord-cb6bd5b742c84021a56ca1cda3c9581f |
| 출처 메모 | uspto-grants-2000_01 |