Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Galantamin → (-)-Galantamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Galantamin | HCID 3449 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Methylephedrine | HCID 64782 | — |
| 반응물 | Narwedine | HCID 10356588 | — |
| 반응물 | n-Ethyl-2-aminopyridine | HCID 19364846 | — |
| 반응물 | Aluminium lithium hydride | HCID 21226445 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | (-)-Galantamine | HCID 9651 | 85% |
반응 단계
(-)-Narwedine (>98% ee, 0.1 g) was added to a mixture of lithium aluminium hydride (1.2 ml of a 1.0 M solution in ether), (-)-N-methylephedrine (0.23 g) and N-ethyl-2-aminopyridine (0.31 g) in ether at 0° C., and the resulting mixture was stirred at that temperature for 4 h. Sodium hydroxide solution (10 ml of a 1.0 M solution) was added and the product extracted with dichloromethane. Evaporation of the organic phase gave (-)-galanthamine (>98% ee, 85% yield) free of epigalanthamine by GC/MS analysis.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06018043 |
| 출처 데이터셋 | uspto-grants-2000_01 |
| ORD ID | ord-08359b98dfe24632af0e79f2f34302e6 |
| 출처 메모 | uspto-grants-2000_01 |