Boron tribromide → 10-bromo-2-hydroxy-5-methyl-4H-pyrido [3,2,1-jk]carbazole-4-one

HRID 850754노트

반응식

HRID 850754 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]3[CH:19]=[C:18]([CH3:20])[C:17](=[O:21])[C:8]4[CH:9]=[C:10]([O:15]C)[CH:11]=[C:12]([C:13]=2[CH:14]=1)[C:7]3=4.B(Br)(Br)Br>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]3[CH:19]=[C:18]([CH3:20])[C:17](=[O:21])[C:8]4[CH:9]=[C:10]([OH:15])[CH:11]=[C:12]([C:13]=2[CH:14]=1)[C:7]3=4

참가 물질

4

반응물 2

HCID 25134Boron tribromideHCID 2125282210-bromo-2-methoxy-5-methyl-4H-pyrido [3,2,1-jk]carbazole-4-one

생성물 1

HCID 2125284210-bromo-2-hydroxy-5-methyl-4H-pyrido [3,2,1-jk]carbazole-4-one수율 99.9%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

10-bromo-2-methoxy-5-methyl-4H-pyrido[3,2,1-jk]carbazole-4-one (4.8 g) obtained in Example 48 was suspended in anhydrous methylene chloride (400 ml), and boron tribromide (25 g) was added dropwise to the suspension at room temperature. The mixture was stirred at room temperature for 12 hours and the reaction mixture was poured into ice water (1500 ml) and the crystals precipitated were recovered by filtration. The resulting crude crystals were washed with ether, and recovered by filtration to obtain the title compound (4.6 g, constant amount).

후처리

  1. customthe crystals precipitated
  2. filtrationwere recovered by filtration
  3. washThe resulting crude crystals were washed with ether
  4. filtrationrecovered by filtration

출처 및 근거

ORD 기록
ord-b350e7d1803d49d695684b58d1a3079f
출처 데이터셋
uspto-grants-2000_01
특허 번호
US06018046

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