Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Nitric Acid → Ethyl 5-nitrothiophene-2-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Nitric Acid | HCID 944 | — |
| 반응물 | Acetic Anhydride | HCID 7918 | — |
| 반응물 | Ethyl 2-thenoate | HCID 76052 | — |
| 생성물 | Ethyl 5-nitrothiophene-2-carboxylate | HCID 304627 | — |
반응 단계
To 160 ml. of acetic anhydride cooled to -5° in an ice-salt bath is added 34 ml. of 90% nitric acid dropwise so that the temperature does not rise above 0°. To this mixture is added 62.7 g. of ethyl 2-thiophenecarboxylate dropwise so that the temperature remains below -5°. Reaction is stirred for 1 hour and poured onto ice. The product is filtered, dried, and recrystallized from hexane.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04382143 |
| 출처 데이터셋 | uspto-grants-1983_05 |
| ORD ID | ord-0a34c26d5c7e47c7b60e97902ce9adb0 |
| 출처 메모 | uspto-grants-1983_05 |