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Dichloromethane → 1-(Methoxycarbonyl)propyl 4-(hexadecylamino)-2-thiophenecarboxylate

HRID 850984
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HRID 850984 반응식
Cl.[CH2:2]([NH:18][C:19]1[CH:20]=[C:21]([C:24](Cl)=[O:25])[S:22][CH:23]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17].C(Cl)Cl.[OH:30][CH:31]([CH2:36][CH3:37])[C:32]([O:34][CH3:35])=[O:33].C(N(CC)CC)C>CCOCC>[CH2:2]([NH:18][C:19]1[CH:20]=[C:21]([C:24]([O:30][CH:31]([C:32]([O:34][CH3:35])=[O:33])[CH2:36][CH3:37])=[O:25])[S:22][CH:23]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 520445Methyl 2-hydroxybutanoateHCID 205036504-Hexadecylamino-2-thiophenecarbonyl chloride hydrochloride

생성물 1

HCID 205036411-(Methoxycarbonyl)propyl 4-(hexadecylamino)-2-thiophenecarboxylate

시약·촉매·용매 1

HCID 3283
Diethyl Ether
용매

실험 절차

To a solution of 10 g. of 4-hexadecylamino-2-thiophenecarbonyl chloride hydrochloride in 200 ml. methylene chloride is added dropwise a solution of 3 g. methyl α-hydroxybutyrate and 5 g. triethylamine in 100 ml. ether. After 17 hours stirring at room temperature, the precipitate is collected and washed with several protions of ether. The ether solution is washed with water, dried and evaporated to yield 1-(methoxycarbonyl)propyl 4-(hexadecylamino)-2-thiophenecarboxylate as a white solid.

후처리

  1. customthe precipitate is collected
  2. washwashed with several protions of ether
  3. washThe ether solution is washed with water
  4. customdried
  5. customevaporated

출처 및 근거

ORD 기록
ord-4d1da3e48c3344e593357643f51c242e
출처 데이터셋
uspto-grants-1983_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04382143

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