Methylamine → N-[[[2-[[5-(Dimethylaminomethyl)-3-thienylmethyl]thio]ethyl]amino](methylamino)methylene]methanesulphonamide

HRID 851113노트

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HRID 851113 반응식
[NH2:1][CH2:2][CH2:3][S:4][CH2:5][C:6]1[CH:7]=[C:8]([CH2:11][N:12]([CH3:14])[CH3:13])[S:9][CH:10]=1.CS[C:17](=[N:20][S:21]([CH3:24])(=[O:23])=[O:22])SC.[CH3:25][NH2:26]>C(O)C>[CH3:13][N:12]([CH2:11][C:8]1[S:9][CH:10]=[C:6]([CH2:5][S:4][CH2:3][CH2:2][NH:1][C:17]([NH:26][CH3:25])=[N:20][S:21]([CH3:24])(=[O:23])=[O:22])[CH:7]=1)[CH3:14]

참가 물질

5

반응물 3

HCID 6329MethylamineHCID 129265012-[(5-Dimethylaminomethyl-3-thienyl)methylthio]ethylamineHCID 13449843N-[bis(methylsulfanyl)methylidene]methanesulfonamide

생성물 1

HCID 178485212N-[[[2-[[5-(Dimethylaminomethyl)-3-thienylmethyl]thio]ethyl]amino](methylamino)methylene]methanesulphonamide

시약·촉매·용매 1

HCID 702Ethanol용매2회

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온도
60 °C

실험 절차

A mixture of 4-[[2-(amino)ethyl]thio]methyl-N,N-dimethyl-2-thiophenemethanamine (0.4 g) and S,S'-dimethyl-N- (methylsulphonyl)-dithio-carbonimidic acid (0.35 g) in ethanol (10 ml) was heated at 60° C. for 1 hour. A 33% solution of methylamine in ethanol (10 ml) was added and the mixture was stirred for 20 h. The solvent was evaporated in vacuo and the residue was purified by column chromatography on silica using methanol to give the title compound (0.5 g) as an amber gum.

후처리

  1. customThe solvent was evaporated in vacuo
  2. customthe residue was purified by column chromatography on silica

출처 및 근거

ORD 기록
ord-97646e3e2fd1497fba083247533837ea
출처 데이터셋
uspto-grants-1983_05
특허 번호
US04382929

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