Phenethyl bromide → 5-(3-Methoxyphenyl)-1-(2-phenylethyl)-1,2,3,6-tetrahydropyridine

HRID 851139노트

반응식

HRID 851139 반응식
Cl.[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:10]2[CH2:11][NH:12][CH2:13][CH2:14][CH:15]=2)[CH:7]=[CH:8][CH:9]=1.C(=O)([O-])[O-].[Na+].[Na+].[CH2:22](Br)[CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>CC(C)=O>[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:10]2[CH2:11][N:12]([CH2:22][CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:13][CH2:14][CH:15]=2)[CH:7]=[CH:8][CH:9]=1

참가 물질

5

반응물 3

HCID 7666Phenethyl bromideHCID 10340Sodium CarbonateHCID 130667493-(3-Methoxyphenyl)-1,2,5,6-tetrahydropyridine hydrochloride

생성물 1

HCID 132342035-(3-Methoxyphenyl)-1-(2-phenylethyl)-1,2,3,6-tetrahydropyridine

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 5 g of 3-(3-methoxyphenyl)-1,2,5,6-tetrahydropyridine hydrochloride, 100 ml of acetone, 7 g of sodium carbonate and 3.5 ml of phenethyl bromide was refluxed for 16 hours and was filtered. The filtrate was evaporated to dryness and the residue was chromatographed over silica gel. The elution with a 7-3 cyclohexane-ethyl acetate mixture yielded 6.2 g of 3-(3-methoxyphenyl)-1-phenethyl-1,2,5,6-tetrahydropyridine.

후처리

  1. temperaturewas refluxed for 16 hours
  2. filtrationwas filtered
  3. customThe filtrate was evaporated to dryness
  4. customthe residue was chromatographed over silica gel
  5. washThe elution with a 7-3 cyclohexane-ethyl acetate mixture

출처 및 근거

ORD 기록
ord-bffbb67ecc56421c96d29c5cb46e51be
출처 데이터셋
uspto-grants-1983_05
특허 번호
US04382942

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