3,4,5-Trimethoxyphenol → 1,2,3,4-Tetrahydro-8,9,10-trimethoxy-5H-[1]benzopyrano[3,4-c]pyridin-5-one hydrochloride

반응식

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([OH:13])[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[ClH:14].O=[C:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH:17]1[C:22](OC)=[O:23]>>[ClH:14].[CH3:12][O:11][C:7]1[C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[C:4]2[C:16]3[CH2:21][CH2:20][NH:19][CH2:18][C:17]=3[C:22](=[O:23])[O:13][C:5]=2[CH:6]=1

참가 물질

반응물 2

HCID 695053,4,5-Trimethoxyphenol

HCID 2724028Methyl 4-oxopiperidine-3-carboxylate hydrochloride

생성물 1

HCID 131369141,2,3,4-Tetrahydro-8,9,10-trimethoxy-5H-[1]benzopyrano[3,4-c]pyridin-5-one hydrochloride수율 55%

실험 절차

Prepared by the method described in Example 1 from 3,4,5-trimethoxyphenol (25 g, 0.14 moles) and methyl 4-oxo-3-piperidinecarboxylate hydrochloride (18.8 g, 0.097 moles). Recrystallization from dilute aqueous hydrochloric acid yielded the product (17.5 g) as the hydrochloride, mp 232°-234° C.

후처리

customPrepared by the method
customRecrystallization from dilute aqueous hydrochloric acid

출처 및 근거

ORD 기록: ord-32bc5c3456fd4bc0b985babfe6c8a89f
출처 데이터셋: uspto-grants-1983_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04382939

반응 노트

불러오는 중…