3,4-Dimethylphenol → 1,2,3,4-Tetrahydro-8,9-dimethyl-5H-[1]benzopyrano[3,4-c]pyridin-5-one

HRID 851186

반응식

HRID 851186 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[CH:6][C:7]=1[CH3:8].Cl.O=[C:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH:13]1[C:18](OC)=[O:19]>>[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5]2[C:12]3[CH2:17][CH2:16][NH:15][CH2:14][C:13]=3[C:18](=[O:19])[O:9][C:4]=2[CH:3]=1

참가 물질

3

반응물 2

HCID 72493,4-DimethylphenolHCID 2724028Methyl 4-oxopiperidine-3-carboxylate hydrochloride

생성물 1

HCID 131369151,2,3,4-Tetrahydro-8,9-dimethyl-5H-[1]benzopyrano[3,4-c]pyridin-5-one수율 84.2%

실험 절차

Prepared by the method described in Example 1 from 3,4-dimethylphenol (10.0 g, 0.082 moles) and methyl 4-oxo-3-piperdinecarboxylate hydrochloride (11.3 g, 0.058 moles). Recrystallization from 2-methoxyethanol yielded the product (11.2 g), mp 172°-l74° C.

후처리

  1. customPrepared by the method
  2. customRecrystallization from 2-methoxyethanol

출처 및 근거

ORD 기록
ord-298921b440f549e6bd10bc5587a43c75
출처 데이터셋
uspto-grants-1983_05
특허 번호
US04382939

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