3-Phenylphenol → 8-Phenyl-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-c]pyridin-5-one

HRID 851192

반응식

HRID 851192 반응식
[C:1]1([C:7]2[CH:8]=[C:9]([OH:13])[CH:10]=[CH:11][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.O=[C:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH:17]1[C:22](OC)=[O:23]>>[C:1]1([C:7]2[CH:12]=[CH:11][C:10]3[C:16]4[CH2:21][CH2:20][NH:19][CH2:18][C:17]=4[C:22](=[O:23])[O:13][C:9]=3[CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

3

반응물 2

HCID 113813-PhenylphenolHCID 2724028Methyl 4-oxopiperidine-3-carboxylate hydrochloride

생성물 1

HCID 131369208-Phenyl-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-c]pyridin-5-one수율 54.1%

실험 절차

Prepared by the method described for Example 1 from 3-phenylphenol (17 g, 0.1 moles) and methyl 4-oxo-3-piperidinecarboxylate hydrochloride (19.3 g, 0.1 moles). The crude material is washed with water and dried to give the product (15 g), mp 250°-270° C.

후처리

  1. customPrepared by the method
  2. washThe crude material is washed with water
  3. customdried

출처 및 근거

ORD 기록
ord-e87a6a2a20fb4204bf05a4a1995653e6
출처 데이터셋
uspto-grants-1983_05
특허 번호
US04382939

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