2-Chloroethanol → Ethanol, 2-chloro-, 1-(4-methylbenzenesulfonate)
반응식
[C:1]1([CH3:11])[CH:6]=[CH:5][C:4]([S:7](Cl)(=[O:9])=[O:8])=[CH:3][CH:2]=1.[Cl:12][CH2:13][CH2:14][OH:15]>N1C=CC=CC=1>[CH3:11][C:1]1[CH:6]=[CH:5][C:4]([S:7]([O:15][CH2:14][CH2:13][Cl:12])(=[O:9])=[O:8])=[CH:3][CH:2]=1참가 물질
4
반응 조건
- 온도
- 2.5 °C
실험 절차
In a typical run, p-toluenesulfonyl chloride (TsCl, 70.5 g, 0.37 mol) was added slowly to a solution of 2-chloroethanol (38; 25.0 g, 0.31 mol) in pyridine (100 mL) at 0° C. The reaction mixture was stirred at 0-5° C. for 18 h. Ice water (300 mL) was added and the resulting mixture was extracted with ethyl acetate (3×100 mL). The combined organic layers were washed with 1 N HCl (3×100 mL), water (100 mL×3), dried (Na2SO4) and concentrated under reduced pressure to afford 2-chloroethyl 4-methylbenzenesulfonate 39 (64.3 g, 88%).
후처리
- extractionthe resulting mixture was extracted with ethyl acetate (3×100 mL)
- washThe combined organic layers were washed with 1 N HCl (3×100 mL), water (100 mL×3)
- dry with materialdried (Na2SO4)
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-8d9e6a3f48bc427483e6475ed283561b
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08846947B2
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