Ammonia → 3-bromo-4-fluorobenzamide

HRID 851288

반응식

HRID 851288 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[F:11])[C:5](F)=[O:6].[NH3:12]>O>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[F:11])[C:5]([NH2:12])=[O:6]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 129227073-Bromo-4-fluorobenzoyl fluoride

생성물 1

HCID 27733293-bromo-4-fluorobenzamide수율 97.5%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

800 g (3.6 moles) of 3-bromo-4-fluoro-benzoyl fluoride were metered into 760 g of 25% strength aqueous ammonia solution (11 moles of NH3), which had been diluted with a further 760 ml of water, at a rate such that an internal temperature of 40° to 50° C. was maintained by the weakly exothermic reaction. After stirring for a further 30 minutes, the crystalline product was isolated by filtration, washed with water and dried. 765 g (97% of theory) of 3-bromo-4-fluoro-benzoic acid amide with a melting point of 131°-133° C. were obtained.

후처리

  1. temperaturewas maintained by the weakly exothermic reaction
  2. customthe crystalline product was isolated by filtration
  3. washwashed with water
  4. customdried

출처 및 근거

ORD 기록
ord-527d56ffb1b642458984fd470ca31e41
출처 데이터셋
uspto-grants-1983_05
특허 번호
US04383949

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