Benzophenone → 1,1-Diphenyl-5-methoxy-1-pentanol

HRID 851301

반응식

HRID 851301 반응식
[Mg].Br[CH2:3][CH2:4][CH2:5][CH2:6][O:7][CH3:8].[C:9]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)(=[O:16])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>CCOCC>[C:17]1([C:9]([C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)([OH:16])[CH2:3][CH2:4][CH2:5][CH2:6][O:7][CH3:8])[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

참가 물질

5

반응물 3

HCID 3102BenzophenoneHCID 5211681-Bromo-4-methoxybutaneHCID 5462224Magnesium

생성물 1

HCID 131250861,1-Diphenyl-5-methoxy-1-pentanol

시약·촉매·용매 1

HCID 3283Diethyl Ether용매3회

실험 절차

To a suspension of 3.9 g. (0.16 mole) of magnesium turnings in 300 ml. of dry ether was added dropwise 26.7 g. (0.16 mole) of 1-bromo-4-methoxybutane in 80 ml. of ether and the mixture refluxed for four hours. The reaction mixture was cooled and 14.6 g. (0.008 mole) of benzophenone in 100 ml. of dry ether was added dropwise. The mixture was stirred at ambient temperature for 18 hours, cautiously quenched with water and the ether layer separated. The aqueous layer was extracted with ether and the combined ether extract was dried and concentrated to give 1,1-diphenyl-5-methoxy-1-pentanol, m.p. 112°-115° C.

후처리

  1. additionTo a suspension of 3.9 g
  2. temperatureThe reaction mixture was cooled
  3. customcautiously quenched with water
  4. customthe ether layer separated
  5. extractionThe aqueous layer was extracted with ether
  6. extractionthe combined ether extract
  7. customwas dried
  8. concentrationconcentrated

출처 및 근거

ORD 기록
ord-f96ea3d11f8141bb8c275c39b317d715
출처 데이터셋
uspto-grants-1983_05
특허 번호
US04383999

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