Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → 1-(2-Methyl-3-phenyl-propyl)-piperidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | 2-Methylcinnamic aldehyde | HCID 7557 | — |
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 1-(2-Methyl-3-phenyl-propyl)-piperidine | HCID 14149584 | — |
반응 단계
A mixture of 1000 g of α-methyl-cinnamaldehyde, 10 liters of methanol and 640 g of piperidine are placed under a nitrogen atmosphere and 50 g of palladium/carbon are added thereto. The mixture is then hydrogenated while cooling with water to 30° C. internal temperature. Hydrogenation continued until the hydrogen uptake has been completed. The catalyst was filtered off and the methanol was distilled under vacuum. Distillation of the crude produce yielded pure 1-(2-methyl-3-phenyl-propyl)-piperidine, b.p. 92° C./0.04 Torr.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04384116 |
| 출처 데이터셋 | uspto-grants-1983_05 |
| ORD ID | ord-8e1a18fbdbb64a47a565f2ed7c64cc37 |
| 출처 메모 | uspto-grants-1983_05 |