Methyl 3-amino-5-morpholino-2-nitrobenzoate → Methyl 2,3-diamino-5-morpholinobenzoate

HRID 85139

반응식

HRID 85139 반응식
[NH2:1][C:2]1[C:3]([N+:18]([O-])=O)=[C:4]([CH:9]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[CH:11]=1)[C:5]([O:7][CH3:8])=[O:6]>CCO.[Pd]>[CH3:8][O:7][C:5](=[O:6])[C:4]1[CH:9]=[C:10]([N:12]2[CH2:13][CH2:14][O:15][CH2:16][CH2:17]2)[CH:11]=[C:2]([NH2:1])[C:3]=1[NH2:18]

참가 물질

4

반응물 1

HCID 58278827Methyl 3-amino-5-morpholino-2-nitrobenzoate

생성물 1

HCID 58279190Methyl 2,3-diamino-5-morpholinobenzoate수율 69.5%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A solution of methyl 3-amino-5-morpholino-2-nitrobenzoate (72; 2.1 g, 7.5 mmol) in EtOH (100 ml) was hydrogenated over 5% Pd/C (200 mg) at room temperature. After 3 h, the reaction mixture was filtered and concentrated under reduced pressure to afford 2,3-diamino-5-morpholin-4-yl-benzoic acid methyl ester 73 (1.3 g, 69.5%) as a brown yellow solid.

후처리

  1. filtrationthe reaction mixture was filtered
  2. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-a0f44400149b41d28949fd764b92d053
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846947B2

연결된 노트

불러오는 중…