Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 85141생성일: 2026년 10월 23일
Hydrochloric Acid → 6-morpholin-4-yl-2-(2-trifluoromethyl-phenyl)-1H-benzoimidazole-4-carboxylic acid
https://huagongshe.com/ko/reaction/85141
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 6-morpholin-4-yl-2-(2-trifluoromethyl-phenyl)-1H-benzoimidazole-4-carboxylic acid methyl ester | HCID 67201807 | — |
| 용매 | Sodium Hydroxide | HCID 14798 | — |
| 생성물 | 6-morpholin-4-yl-2-(2-trifluoromethyl-phenyl)-1H-benzoimidazole-4-carboxylic acid | HCID 67202385 | 93% |
반응 단계
A mixture containing 6-morpholin-4-yl-2-(2-trifluoromethyl-phenyl)-1H-benzoimidazole-4-carboxylic acid methyl ester (75; 670 mg, 1.65 mmol) in 1M NaOH (27 ml) was stirred at 70° C. for 30 min. The reaction mixture was neutralized with 10% aqueous HCl. The resulting precipitate was collected by filtration and dried to afford 6-morpholin-4-yl-2-(2-trifluoromethyl-phenyl)-1H-benzoimidazole-4-carboxylic acid 76 (600 mg, 93%) as a pale yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08846947B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_09 |
|---|
| ORD ID | ord-f2382b72b62b4358bbb4218ab9da4204 |
|---|
| 출처 메모 | uspto-grants-2014_09 |
|---|
