2-Hydroxy-4-methyl-hydratropic acid phenylurethane → 2-(4-Tolyl)propanoic acid

HRID 851468

반응식

HRID 851468 반응식
C1(NC(OCC)=O)C=CC=CC=1.O[C:14]1[CH:24]=[C:23]([CH3:25])[CH:22]=[CH:21][C:15]=1[CH:16]([CH3:20])[C:17]([OH:19])=[O:18].[H][H]>C(O)(=O)C.[Pd]>[CH3:25][C:23]1[CH:22]=[CH:21][C:15]([CH:16]([CH3:20])[C:17]([OH:19])=[O:18])=[CH:14][CH:24]=1

참가 물질

5

반응물 2

HCID 705129172-Hydroxy-4-methyl-hydratropic acid phenylurethaneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 1508662-(4-Tolyl)propanoic acid수율 67%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 176Acetic Acid용매

실험 절차

3 g. of 2-hydroxy-4-methyl-hydratropic acid phenylurethane are dissolved in acetic acid. To the solution 0.4 g. of a 5% palladium-on-charcoal catalyst are added, and the mixture is hydrogenated at 25° C. until the calculated amount of hydrogen is used up. The catalyst is filtered off and the filtrate is evaporated. The residue is admixed with a 10% aqueous hydrochloric acid solution and the separated oil is extracted with chloroform. The chloroform solution is dried over sodium sulphate and evaporated. 1.1 g. (67%) of 4-methyl-hydratropic acid are obtained.

후처리

  1. filtrationThe catalyst is filtered off
  2. customthe filtrate is evaporated
  3. extractionthe separated oil is extracted with chloroform
  4. dry with materialThe chloroform solution is dried over sodium sulphate
  5. customevaporated

출처 및 근거

ORD 기록
ord-bfe6bd638a6e4612ac6456b8900be82f
출처 데이터셋
uspto-grants-1983_05
특허 번호
US04385004

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