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o-(Trifluoromethyl)benzaldehyde → HCID 67203503, 화합물

HRID 85147
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HRID 85147 반응식
[NH2:1][C:2]1[C:10]([NH2:11])=[CH:9][C:8]([O:12][CH3:13])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[F:14][C:15]([F:25])([F:24])[C:16]1[CH:23]=[CH:22][CH:21]=[CH:20][C:17]=1[CH:18]=O.S(S([O-])=O)([O-])(=O)=O.[Na+].[Na+]>CN(C=O)C.O>[CH3:13][O:12][C:8]1[CH:7]=[C:3]([C:4]([OH:6])=[O:5])[C:2]2[N:1]=[C:18]([C:17]3[CH:20]=[CH:21][CH:22]=[CH:23][C:16]=3[C:15]([F:14])([F:24])[F:25])[NH:11][C:10]=2[CH:9]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 123067o-(Trifluoromethyl)benzaldehydeHCID 656671Sodium PyrosulfiteHCID 58279044HCID 58279044, 화합물

생성물 1

HCID 67203503HCID 67203503, 화합물수율 40%

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

A mixture of 2,3-diamino-5-methoxybenzoic acid 86 (1.1 equiv) and 2-(trifluoromethyl)benzaldehyde 74 (1 equiv) and sodium metabisulfite (3 equiv) in DMF was stirred under reflux for 12 h. Upon cooling to room temperature, the reaction mixture was diluted with water. The resulting solids were collected by filtration and dried to afford 6-methoxy-2-(2-(trifluoromethyl)phenyl)-1H-benzo[d]imidazole-4-carboxylic acid 87 as dark yellow solid (40%).

후처리

  1. temperatureunder reflux for 12 h
  2. filtrationThe resulting solids were collected by filtration
  3. customdried

출처 및 근거

ORD 기록
ord-255f94cbd71c401ea87af6038a02ec98
출처 데이터셋
uspto-grants-2014_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08846947B2

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