Ammonia → BOC-Nva-Met-NH2

HRID 851722노트

반응식

HRID 851722 반응식
[NH:1]([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[C@H:2]([C:6]([NH:8][C@H:9]([C:14](OC)=[O:15])[CH2:10][CH2:11][S:12][CH3:13])=[O:7])[CH2:3][CH2:4][CH3:5].[NH3:25]>CO>[C:21]([O:20][C:18]([NH:1][C@H:2]([C:6]([NH:8][C@H:9]([C:14]([NH2:25])=[O:15])[CH2:10][CH2:11][S:12][CH3:13])=[O:7])[CH2:3][CH2:4][CH3:5])=[O:19])([CH3:24])([CH3:23])[CH3:22]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 57129312BOC-Nva-Met-OMe

생성물 1

HCID 57006973BOC-Nva-Met-NH2

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

1.81 g (5 mmoles) of BOC-Nva-Met-OMe are dissolved in 20 ml of methanol, and gaseous ammonia is introduced into the solution for 0.5 hours under ice cooling. The reaction mixture is allowed to stand at room temperature overnight, and then stored in a cold place for some hours. The separated crystalline product is filtered off to obtain 1.27 g of the desired product. The filtrate is evaporated, and the residue is recrystallized from 5 ml of ethanol to obtain further 0.35 g of the product. Thus 1.62 g (93%) of BOC-Nva-Met-NH2 are obtained; m.p.: 166°-167° C., Rf2 =0.57, [α]D25 =-40.9° (c=1%, in methanol).

후처리

  1. waitstored in a cold place for some hours
  2. filtrationThe separated crystalline product is filtered off

출처 및 근거

ORD 기록
ord-1b9055973adf431eb7700a171389b852
출처 데이터셋
uspto-grants-1983_05
특허 번호
US04386073

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