5-Methyl-4-(4-nitro-phenyl)-imidazole → 4-(5-Methyl-1H-imidazol-4-yl)aniline

HRID 851748노트

반응식

HRID 851748 반응식
[CH3:1][C:2]1[NH:6][CH:5]=[N:4][C:3]=1[C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[CH:9][CH:8]=1.[H][H]>CO.[Pd]>[CH3:1][C:2]1[NH:6][CH:5]=[N:4][C:3]=1[C:7]1[CH:12]=[CH:11][C:10]([NH2:13])=[CH:9][CH:8]=1

참가 물질

5

반응물 2

HCID 235073515-Methyl-4-(4-nitro-phenyl)-imidazoleHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 235076304-(5-Methyl-1H-imidazol-4-yl)aniline수율 88%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

Sixty grams of 5-methyl-4-(4-nitrophenyl)-1-H-imidazole dissolved in methanol was hydrogenated in the presence of 0.7 gm of 5% Pd catalyst at atmospheric pressure and at room temperature. When the calculated amount of hydrogen was taken up, the catalyst was filtered off, and the solution was evaporated to dryness to yield 45 gm of 5-methyl-4-(4-aminophenyl)-1-H-imidazole.

후처리

  1. filtrationthe catalyst was filtered off
  2. customthe solution was evaporated to dryness

출처 및 근거

ORD 기록
ord-900f2d852ef0466183ad7397bf58a7f1
출처 데이터셋
uspto-grants-1983_05
특허 번호
US04386099

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