2-Methylbenzimidazole → 1-[2-[2-(2-Methoxyethoxy)ethoxy]ethyl]-2-methyl-1H-benzimidazole

반응식

[CH3:1][C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[CH3:11][O:12][CH2:13][CH2:14][O:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20]Cl>>[CH3:11][O:12][CH2:13][CH2:14][O:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20][N:3]1[C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=[C:2]1[CH3:1]

참가 물질

반응물 2

HCID 119842-Methylbenzimidazole

HCID 5478521-Chloro-3,6,9-trioxadecane

생성물 1

HCID 589270931-[2-[2-(2-Methoxyethoxy)ethoxy]ethyl]-2-methyl-1H-benzimidazole수율 82%

실험 절차

1-[2-[2-(2-Methoxyethoxy)ethoxy]ethyl]-2-methyl-1H-benzimidazole was synthesized as in Synthesis Example 1 except that an equimolar amount of 2-methylbenzimidazole was used instead of benzimidazole and an equimolar amount of 2-chloroethyl 2-(2-methoxyethoxy)ethyl ether was used instead of 2-chloroethyl methyl ether. Yield 82%.

출처 및 근거

ORD 기록: ord-a7fef564d53346fdbb79d60b96c60848
출처 데이터셋: uspto-grants-2007_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07252925B2

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